期刊
ADVANCED MATERIALS
卷 28, 期 27, 页码 5648-5661出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201505349
关键词
biomaterials; cardiac tissue engineering; drug delivery; hydrogels; stem cell therapy
类别
资金
- Science Foundation Ireland (SFI) [SFI/12/RC/2278, SFI/13/IA/1840]
- BioAT funding bodies PRTL (Programme for Research in Third Level Institutions) Cycle 5
- European Regional Development Fund (ERDF), part of the European Union Structural Funds Programme
- European Research Council from European Union [239685]
- AMCARE grant from European Union [604531]
- European Union [645911]
- European Research Council (ERC) [239685] Funding Source: European Research Council (ERC)
Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.
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