期刊
ADVANCED MATERIALS
卷 28, 期 33, 页码 7143-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201602111
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资金
- National Natural Science Foundation of China [51525203, 51302180]
- National 973 Program of China [2012CB932601]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Post-doctoral science foundation of China [2014M561706]
A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance.
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