期刊
ADVANCED MATERIALS
卷 28, 期 34, 页码 7365-7374出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601900
关键词
induced neuronal cells; in vivo reprogramming; neuronal maturation; nonviral direct conversion; triboelectric nanogenerators
类别
资金
- National Research Foundation of Korea (NRF) [2012-0006689, 2013R1A1A2A10061422, 2015R1A2A1A15053771]
- Korea Health Technology R&D Project - Ministry of Health and Welfare, Republic of Korea [HI13C1479]
- Mid-Career Researcher Program through an NRF - MEST [2014R1A2A2A09053061]
- sensitivity touch platform development and new industrialization support program through the Ministry of Trade, Industry Energy (MOTIE)
- Korea Institute for Advancement of Technology (KIAT) [R0003423]
- Yonsei University IACUC [IACUC-A-201507-348-01]
- Korea Health Promotion Institute [HI13C1479040015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0093823, 2015R1A2A1A15053771, 2013R1A1A2A10061422] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Triboelectric nanogenerators (TENGs) can be an effective cell reprogramming platform for producing functional neuronal cells for therapeutic applications. Triboelectric stimulation accelerates nonviral direct conversion of functional induced neuronal cells from fibroblasts, increases the conversion efficiency, and induces highly matured neuronal phenotypes with improved electrophysiological functionalities. TENG devices may also be used for biomedical in vivo reprogramming.
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