4.8 Article

Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses

期刊

ADVANCED MATERIALS
卷 28, 期 12, 页码 2417-2420

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201504527

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资金

  1. Office of Naval Research [N00014-13-1-0596]
  2. National Defense Science and Engineering Graduate Fellowship
  3. Tufts University Graduate Student Research Competition

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A novel method to photocrosslink silk fibroin protein is reported, using riboflavin (vitamin B2) as a photoinitiator and the mechanism of crosslinking is determined. Exposure of riboflavin-doped liquid silk solution to light results in the formation of a transparent, elastic hydrogel. Several applications for this new material are investigated including corneal reshaping to restore visual acuity and photolithography. [GRAPHICS] .

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