相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Natural Product Gossypol and its Derivaties in Percision Cancer Medicine
Yun Zeng et al.
CURRENT MEDICINAL CHEMISTRY (2019)
Measuring RNA-Ligand Interactions with Microscale Thermophoresis
Michelle H. Moon et al.
BIOCHEMISTRY (2018)
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
Lorenzo I. Finci et al.
GENES & DEVELOPMENT (2018)
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors
Leonardo Manzoni et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Pathomechanisms of TDP-43 in neurodegeneration
Ju Gao et al.
JOURNAL OF NEUROCHEMISTRY (2018)
Thermophoresis for characterizing biomolecular interaction
Mufarreh Asmari et al.
METHODS (2018)
The PPAR gamma agonist rosiglitazone sensitizes the BH3 mimetic (-)-gossypol to induce apoptosis in cancer cells with high level of Bcl-2
Xinzhe Li et al.
MOLECULAR CARCINOGENESIS (2018)
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
Michael Seiler et al.
NATURE MEDICINE (2018)
Principles for targeting RNA with drug-like small molecules
Katherine Deigan Warner et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
A brave new world of RNA-binding proteins
Matthias W. Hentze et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28
Longfei Wang et al.
CELL REPORTS (2018)
Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFRL858R/T790M
Yuwei Wang et al.
FRONTIERS IN PHARMACOLOGY (2018)
Anti-inflammatory Effects of Gossypol on Human Lymphocytic Jurkat Cells via Regulation of MAPK Signaling and Cell Cycle
Chien-Wei Chen et al.
INFLAMMATION (2018)
Musashi RNA- binding protein 2 regulates estrogen receptor 1 function in breast cancer
M-H Kang et al.
ONCOGENE (2017)
Discovery of BAZ2A bromodomain ligands
Dimitrios Spiliotopoulos et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
The role of RNA-binding protein tristetraprolin in cancer and immunity
Jian Guo et al.
MEDICAL ONCOLOGY (2017)
Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition
Andreas Schlundt et al.
METHODS (2017)
Gossypol induces cell death by activating apoptosis and autophagy in HT-29 cells
Ming-Dong Lu et al.
MOLECULAR MEDICINE REPORTS (2017)
Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA
Ryo Iwaoka et al.
MOLECULES (2017)
Regulation of HuR structure and function by dihydrotanshinone-I
Preet Lal et al.
NUCLEIC ACIDS RESEARCH (2017)
Therapeutic targeting of RNA splicing in myelodysplasia
Young Joon Kim et al.
SEMINARS IN HEMATOLOGY (2017)
Overexpression of Musashi-1 protein is associated with progression and poor prognosis of gastric cancer
Zhangxuan Shou et al.
ONCOLOGY LETTERS (2017)
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
Cara Lunn Shirai et al.
NATURE COMMUNICATIONS (2017)
LIN28 Zinc Knuckle Domain is Required and Sufficient to Induce let-7 Oligouridylation
Longfei Wang et al.
CELL REPORTS (2017)
The LIN28/let-7 Pathway in Cancer
Julien Balzeau et al.
FRONTIERS IN GENETICS (2017)
Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells
Gunhild Sommer et al.
PLOS ONE (2017)
Recent Advances in Targeting the HIV-1 Tat/TAR Complex
Fardokht A. Abulwerdi et al.
CURRENT PHARMACEUTICAL DESIGN (2017)
Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets
Alexander E. Kudinov et al.
CLINICAL CANCER RESEARCH (2017)
Stem Cells, Cancer, and MUSASHI in Blood and Guts
Michael G. Kharas et al.
TRENDS IN CANCER (2017)
Gossypol has anti-cancer effects by dual targeting MDM2 and VEGF in human breast cancer
Jing Xiong et al.
BREAST CANCER RESEARCH (2017)
Global vision of druggability issues: applications and perspectives
Hiba Abi Hussein et al.
DRUG DISCOVERY TODAY (2017)
High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography
Graziano Lolli et al.
ACS CHEMICAL BIOLOGY (2016)
A Small-Molecule Inhibitor of Lin28
Martina Roos et al.
ACS CHEMICAL BIOLOGY (2016)
Targeting transcription factors by small compounds-Current strategies and future implications
Judith Hagenbuchner et al.
BIOCHEMICAL PHARMACOLOGY (2016)
Sensing of biomolecular interactions using fluorescence complementing systems in living cells
Xian-En Zhang et al.
BIOSENSORS & BIOELECTRONICS (2016)
Physiologic Expression of Sf3b1K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation
Esther A. Obeng et al.
CANCER CELL (2016)
Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment
Lubing Gu et al.
CANCER CELL (2016)
The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer
Elisa Latorre et al.
CANCER RESEARCH (2016)
Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies
Christine K. Maurer et al.
FUTURE MEDICINAL CHEMISTRY (2016)
RNA regulation went wrong in neurodevelopmental disorders: The example of Msi/Elavl RNA binding proteins
Masato Yano et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2016)
Musashi-2 is a novel regulator of paclitaxel sensitivity in ovarian cancer cells
Jeongsuk Lee et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2016)
Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation
Jean-Remy Marchand et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery of a Small-Molecule Inhibitor of Protein-MicroRNA Interaction Using Binding Assay with a Site-Specifically Labeled Lin28
Donghyun Lim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations
Constantin Cretu et al.
MOLECULAR CELL (2016)
Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells
Stefan Rentas et al.
NATURE (2016)
Targeting renal cell carcinoma with a HIF-2 antagonist
Wenfang Chen et al.
NATURE (2016)
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey et al.
NATURE (2016)
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
Stanley Chun-Wei Lee et al.
NATURE MEDICINE (2016)
Therapeutic targeting of splicing in cancer
Stanley Chun-Wei Lee et al.
NATURE MEDICINE (2016)
Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
Helen L. Lightfoot et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2016)
Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform
Liangxian Cao et al.
PLOS ONE (2016)
Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis
Alexander E. Kudinov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Structure of a yeast activated spliceosome at 3.5 Å resolution
Chuangye Yan et al.
SCIENCE (2016)
Tristetraprolin as a Therapeutic Target in Inflammatory Disease
Sonika Patial et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction
Xiaoqing Wu et al.
ACS CHEMICAL BIOLOGY (2015)
Masashi Signaling in Stem Cells and Cancer
Raymond G. Fox et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31 (2015)
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
Giovanni Ciriello et al.
CELL (2015)
Targeting the Multifaceted HuR Protein, Benefits and Caveats
Chiara Zucal et al.
CURRENT DRUG TARGETS (2015)
B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo
Amy DeMicco et al.
JOURNAL OF IMMUNOLOGY (2015)
New Frontiers in Druggability
Dima Kozakov et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Identification of recurrent regulated alternative splicing events across human solid tumors
Miri Danan-Gotthold et al.
NUCLEIC ACIDS RESEARCH (2015)
Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin
Yixiang Han et al.
PLOS ONE (2015)
Correlation of Musashi-1, Lgr5, and pEGFR expressions in human small intestinal adenocarcinomas
Yan Wang et al.
TUMOR BIOLOGY (2015)
Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function
Vito Giuseppe D'Agostino et al.
Scientific Reports (2015)
Widespread intron retention diversifies most cancer transcriptomes
Heidi Dvinge et al.
GENOME MEDICINE (2015)
Integrative analysis of cancer imaging readouts by networks
Marco Daminietto et al.
MOLECULAR ONCOLOGY (2015)
Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide-Herboxidiene Hybrid Analog and Related Derivatives
Chandraiah Lagisetti et al.
ACS CHEMICAL BIOLOGY (2014)
Ligand induced stabilization of the melting temperature of the HSV-1 single-strand DNA binding protein using the thermal shift assay
Kanchi Ravi Rupesh et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models
Liem H. Nguyen et al.
CANCER CELL (2014)
Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Antonina Giammanco et al.
CANCER RESEARCH (2014)
A 1536-Well Fluorescence Polarization Assay to Screen for Modulators of the MUSASHI Family of RNA-Binding Proteins
Gerard Minuesa et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2014)
Lin28 sustains early renal progenitors and induces Wilms tumor
Achia Urbach et al.
GENES & DEVELOPMENT (2014)
A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors
D. S. Hong et al.
INVESTIGATIONAL NEW DRUGS (2014)
A Conserved Three-nucleotide Core Motif Defines Musashi RNA Binding Specificity
N. Ruth Zearfoss et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Present and future of NMR for RNA-protein complexes: A perspective of integrated structural biology
Teresa Carlomagno
JOURNAL OF MAGNETIC RESONANCE (2014)
RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway
Lan Liu et al.
MOLECULAR BIOLOGY OF THE CELL (2014)
Conditional Knockout of the RNA-Binding Protein HuR in CD4+ T Cells Reveals a Gene Dosage Effect on Cytokine Production
Matthew M. Gubin et al.
MOLECULAR MEDICINE (2014)
Post-transcriptional coordination of immunological responses by RNA-binding proteins
Panagiota Kafasla et al.
NATURE IMMUNOLOGY (2014)
A census of human RNA-binding proteins
Stefanie Gerstberger et al.
NATURE REVIEWS GENETICS (2014)
Clinical significance of HuR expression in human malignancy
Ioly Kotta-Loizou et al.
MEDICAL ONCOLOGY (2014)
Screening protein - Single stranded RNA complexes by NMR spectroscopy for structure determination
Lle N. Foot et al.
METHODS (2014)
Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity
Franziska Bollmann et al.
NUCLEIC ACIDS RESEARCH (2014)
In vivo imaging of protein-protein and RNA-protein interactions using novel far-red fluorescence complementation systems
Yu Han et al.
NUCLEIC ACIDS RESEARCH (2014)
Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery
Disha Patel et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2014)
TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?
Lies Vanden Broeck et al.
TRENDS IN MOLECULAR MEDICINE (2014)
The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding
Hong Wang et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2013)
Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA
Shou Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy
Jun Wang et al.
BREAST CANCER RESEARCH AND TREATMENT (2013)
Lin28: Primal Regulator of Growth and Metabolism in Stem Cells
Ng Shyh-Chang et al.
CELL STEM CELL (2013)
HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery
Bainan Wu et al.
CHEMISTRY & BIOLOGY (2013)
Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
Ferry A. L. M. Eskens et al.
CLINICAL CANCER RESEARCH (2013)
LIN28/LIN28B: An emerging oncogenic driver in cancer stem cells
Jianbiao Zhou et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)
An Overview of Biological Macromolecule Crystallization
Irene Russo Krauss et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Analysis of Small Molecule Ligands Targeting the HIV-1 Matrix Protein-RNA Binding Site
Ayna Alfadhli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
A compendium of RNA-binding motifs for decoding gene regulation
Debashish Ray et al.
NATURE (2013)
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
J. William Harbour et al.
NATURE GENETICS (2013)
A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation
Vito G. D'Agostino et al.
PLOS ONE (2013)
Imaging of mRNA-Protein Interactions in Live Cells Using Novel mCherry Trimolecular Fluorescence Complementation Systems
Juan Yin et al.
PLOS ONE (2013)
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Marcin Imielinski et al.
CELL (2012)
HuR function in disease
Subramanya Srikantan et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2012)
The Protein Zfand5 Binds and Stabilizes mRNAs with AU-rich Elements in Their 3′-Untranslated Regions
Guoan He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Combining Global and Local Measures for Structure-Based Druggability Predictions
Andrea Volkamer et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
Anthie Yiakouvaki et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance
Melissa L. Wilbert et al.
MOLECULAR CELL (2012)
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
Jan J. Molenaar et al.
NATURE GENETICS (2012)
Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions
Takako Ohyama et al.
NUCLEIC ACIDS RESEARCH (2012)
The Lin28 cold-shock domain remodels pre-let-7 microRNA
Florian Mayr et al.
NUCLEIC ACIDS RESEARCH (2012)
Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7)
James E. Thornton et al.
RNA (2012)
Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing
Liying Fan et al.
ACS CHEMICAL BIOLOGY (2011)
Assessing protein-RNA interactions using microfluidic capillary mobility shift assays
Jimmy Fourtounis et al.
ANALYTICAL BIOCHEMISTRY (2011)
MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia
Richard J. Byers et al.
BLOOD (2011)
Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
Yunsun Nam et al.
CELL (2011)
Role of RNA binding protein HuR in ductal carcinoma in situ of the breast
Mira Heinonen et al.
JOURNAL OF PATHOLOGY (2011)
Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability
Neelanjan Mukherjee et al.
MOLECULAR CELL (2011)
From unwinding to clamping - the DEAD box RNA helicase family
Patrick Linder et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
Lili Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
Sonia Melo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes
John M. Pagano et al.
RNA (2011)
Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds
Christopher Southan et al.
JOURNAL OF CHEMINFORMATICS (2011)
Aptamer sandwich assays: label-free and fluorescence investigations of heterogeneous binding events
Katie A. Edwards et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2010)
TDP-43: A DNA and RNA binding protein with roles in neurodegenerative diseases
Sadaf T. Warraich et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
Accessing new chemical space for 'undruggable' targets
Sivaraman Dandapani et al.
NATURE CHEMICAL BIOLOGY (2010)
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
Michael G. Kharas et al.
NATURE MEDICINE (2010)
Posttranscriptional regulation of cancer traits by HuR
Kotb Abdelmohsen et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2010)
Development of a Novel Nonradiometric Assay for Nucleic Acid Binding to TDP-43 Suitable for High-Throughput Screening Using AlphaScreen® Technology
Joel A. Cassel et al.
JOURNAL OF BIOMOLECULAR SCREENING (2010)
High-throughput assays probing protein-RNA interactions of eukaryotic translation initiation factors
Gabriela Galicia-Vazquez et al.
ANALYTICAL BIOCHEMISTRY (2009)
Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
Min-Ju Chae et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2009)
The RNA-Binding Protein Elavl1/HuR Is Essential for Placental Branching Morphogenesis and Embryonic Development
Vicky Katsanou et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Regulation of Bcl-2 Expression by HuR in HL60 Leukemia Cells and A431 Carcinoma Cells
Daniella Ishimaru et al.
MOLECULAR CANCER RESEARCH (2009)
Coordinated posttranscriptional mRNA population dynamics during T-cell activation
Neelanjan Mukherjee et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
Lin28 promotes transformation and is associated with advanced human malignancies
Srinivas R. Viswanathan et al.
NATURE GENETICS (2009)
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
John P. Hagan et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation
Wijdan Al-Ahmadi et al.
NUCLEIC ACIDS RESEARCH (2009)
In vivo detection of RNA-binding protein interactions with cognate RNA sequences by fluorescence resonance energy transfer
Martina Huranova et al.
RNA (2009)
Applications of isothermal titration calorimetry in protein science
Yi Liang
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2008)
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
Kotb Abdelmohsen et al.
BIOLOGICAL CHEMISTRY (2008)
Diverse molecular functions of Hu proteins
M. N. Hinman et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia
Ian R. A. Mackenzie et al.
CURRENT OPINION IN NEUROLOGY (2008)
RNA recognition motifs:: boring?: Not quite
Antoine Clery et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2008)
Structure and function of KH domains
Roberto Valverde et al.
FEBS JOURNAL (2008)
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease
Emanuele Buratti et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition
Jose M. Izquierdo
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
Inha Heo et al.
MOLECULAR CELL (2008)
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
Agnieszka Rybak et al.
NATURE CELL BIOLOGY (2008)
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
Martin A. Newman et al.
RNA (2008)
Selective blockade of MicroRNA processing by Lin28
Srinivas R. Viswanathan et al.
SCIENCE (2008)
Development of an HTS assay for the search of anti-influenza agents targeting the interaction of viral RNA with the NS1 protein
Marta Maroto et al.
JOURNAL OF BIOMOLECULAR SCREENING (2008)
RNA-Binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1 alpha
Stefanie Galban et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Assay optimization and screening of RNA-protein interactions by AlphaScreen
Nicholas L. Mills et al.
JOURNAL OF BIOMOLECULAR SCREENING (2007)
Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake et al.
NATURE CHEMICAL BIOLOGY (2007)
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida et al.
NATURE CHEMICAL BIOLOGY (2007)
Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
Nicole-Claudia Meisner et al.
NATURE CHEMICAL BIOLOGY (2007)
RNA-binding proteins: modular design for efficient function
Bradley M. Lunde et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Posttranscriptional orchestration of an anti-apoptotic program by HuR
Kotb Abdelmohsen et al.
CELL CYCLE (2007)
Targeting the vascular endothelial growth factor pathway in the treatment of human malignancy
James R. Tonra et al.
IMMUNOLOGICAL INVESTIGATIONS (2007)
Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma
Yingqiu Guo et al.
GENE (2006)
Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2
Carsten Denkert et al.
MODERN PATHOLOGY (2006)
HuR as a negative posttranscriptional modulator in inflammation
V Katsanou et al.
MOLECULAR CELL (2005)
Understanding nature's design for a nanosyringe
CF Lopez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107 III.: In vitro and In vivo antitumor activities
Y Mizui et al.
JOURNAL OF ANTIBIOTICS (2004)
Crystallization of RNA and RNA-protein complexes
A Ke et al.
METHODS (2004)
Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites
EG Moss et al.
DEVELOPMENTAL BIOLOGY (2003)
Hu protein R-mediated posttranscriptional regulation of VEGF expression in rat gastrocnemius muscle
KC Tang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
The druggable genome
AL Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Kinetic studies of RNA-protein interactions using surface plasmon resonance
PS Katsamba et al.
METHODS (2002)
Messenger-RNA-binding proteins and the messages they carry
G Dreyfuss et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence
WG Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Merged screening for human immunodeficiency virus Tat and Rev inhibitors
F Hamy et al.
JOURNAL OF BIOMOLECULAR SCREENING (2001)
HuR and mRNA stability
CM Brennan et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2001)
HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation
WG Wang et al.
EMBO JOURNAL (2000)
分享论文
