期刊
NATURE BIOMEDICAL ENGINEERING
卷 2, 期 11, 页码 865-877出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-018-0317-8
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资金
- University of Wisconsin-Madison, National Institutes of Health [1R01GM104960, P30CA014520, T32CA009206]
- National Natural Science Foundation of China [31771036, 51703132, 51573096]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Fok Ying-Tong Education Foundation for Young Teachers in Higher Education Institutions of China [161032]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20160422091238319]
- National Key R&D Program of China [2016YFA0201200]
- NSFC [21329501, 21390414]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH031]
- National Research Foundation of Korea [21A20130000016] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Patients with acute kidney injury (AKI) frequently require kidney transplantation and supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled DNA origami nanostructures (DONs) with rectangular, triangular and tubular shapes accumulate preferentially in the kidneys of healthy mice and mice with rhabdomyolysis-induced AKI, and that rectangular DONs have renal-protective properties, with efficacy similar to the antioxidant N-acetylcysteine-a clinically used drug that ameliorates contrast-induced AKI and protects kidney function from nephrotoxic agents. We evaluated the biodistribution of DONs non-invasively via positron emission tomography, and the efficacy of rectangular DONs in the treatment of AKI via dynamic positron emission tomography imaging with Ga-68-EDTA, blood tests and kidney tissue staining. DNA-based nanostructures could become a source of therapeutic agents for the treatment of AKI and other renal diseases.
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