期刊
ADVANCED MATERIALS
卷 28, 期 37, 页码 8162-8168出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601101
关键词
drug delivery; nanoparticles; optical imaging; renal clearance; theranostics
类别
资金
- European Project FP7 [PIOF-GA-2011-303069]
- NIH/NIBIB [R01-EB-011523]
- France Live Imaging (FLI-Grenoble
- Infrastructure d'avenir en Biologie Sante) [ANR-11-NBS-0006]
- Basic Science Research Program through the NRF of Korea [NRF-2014-R1A6A3A03057790]
Renally cleared zwitterionic nanocarriers (H-Dots) are composed of a epsilon-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and beta-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution, and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.
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