期刊
ADVANCED FUNCTIONAL MATERIALS
卷 26, 期 24, 页码 4252-4261出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201600985
关键词
cancer theranostics; carbon; nanocapsule; photothermal therapy; synergistic effect
类别
资金
- National Nature Science Foundation [31270022, 81471784, 51477169, 31271075, 51572271]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2015023]
- 100 Talents Program of the Chinese Academy of Sciences
- Fundamental Research Funds for the Central Universities [JC1502]
- Thousands Talents program for pioneer researchers and his innovation team, China
Carbon-based nanomaterials have been developed for photothermal cancer therapy, but it is still a great challenge to fabricate their multifunctional counterparts with facile methods, good biocompatibility and dispersity, and high efficiency for cancer theranostics. In this work, an alternative multifunctional nanoplatform is developed based on carbon-silica nanocapsules with gold nanoparticle in the cavity (Au@CSN) for cancer theranostics. The encapsulated chemodrug doxorubicin can be released from the Au@CSN with mesoporous and hollow structure in a near-infrared light and pH stimuli-responsive manner, facilitating spatiotemporal therapy to decrease off-target toxicity. The nanocapsules with efficient photothermal conversion and excellent biocompatibility achieve a synergistic effect of photothermal and chemotherapy. Furthermore, the nanocapsules can act as a multimodal imaging agent of computed tomography and photoacoustic tomography imaging for guiding the therapy. This new design platform can provide a promising strategy for precise cancer theranostics.
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