4.8 Article

One-Pot Synthesis of Dual Stimulus-Responsive Degradable Hollow Hybrid Nanoparticles for Image-Guided Trimodal Therapy

期刊

ADVANCED FUNCTIONAL MATERIALS
卷 26, 期 47, 页码 8613-8622

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201603394

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资金

  1. Japan Society for the Promotion of Science (JSPS) [26709050, 15K14146]
  2. Health Labor Sciences Research Grant from the Ministry of Health, Labor and Welfare
  3. Long-range Research Initiative (LRI) grant from the Japan Chemical Industry Association (JCIA)
  4. Grants-in-Aid for Scientific Research [16K01358, 26709050, 15K14146] Funding Source: KAKEN

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Exploiting exogenous and endogenous stimulus-responsive degradable nanoparticles as drug carriers can improve drug delivery systems (DDSs). The use of hollow nanoparticles may facilitate degradation, and combination of DDS with photodynamic therapy (PDT) and photothermal therapy (PTT) may enhance the anticancer effects of treatments. Here, a one-pot synthetic method is presented for an anticancer drug (doxorubicin [DOX]) and photosensitizer-containing hollow hybrid nanoparticles (HNPs) with a disulfide and siloxane framework formed in response to exogenous (light) and endogenous (intracellular glutathione [GSH]) stimuli. The hollow HNPs emit fluorescence within the near-infrared window and allow for the detection of tumors in vivo by fluorescence imaging. Furthermore, the disulfides within the HNP framework are cleaved by intracellular GSH, deforming the HNPs. Light irradiation facilitates penetration of GSH into the HNP framework and leads to the collapse of the HNPs. As a result, DOX is released from the hollow HNPs. Additionally, the hollow HNPs generate singlet oxygen (O-1(2)) and heat in response to light; thus, fluorescence imaging of tumors combined with trimodal therapy consisting of DDS, PDT, and PTT is feasible, resulting in superior therapeutic efficacy. Thus, this method may have several applications in imaging and therapeutics in the future.

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