期刊
PHARMACEUTICS
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics11010025
关键词
carbosilane; dendrimers; anticancer siRNA; nucleic acids; dendriplexes; complexation; transfection; cytotoxicity; biophysical assays
资金
- RFBR [16-33-60152, 18-33-20109]
- MINECO [CTQ-2017-85224-P]
- Consortium NANODENDMED-II-CM [B2017/BMD-3703]
- IMMUNOTHERCAN-CM [B2017/BMD3733]
- Marie Curie International Research Staff Exchange Scheme Fellowship within the 7th European Community Framework Programme [PIRSES-GA-2012-316730 NANOGENE]
- Russian Federation [1778.2015.4, 882.2016.4]
- FASIE grant [3649GU1/2014]
- VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions
- Instituto de Salud Carlos III
- European Regional Development Fund
- University of Alcala
This paper examines the complexation of anti-cancer small interfering RNAs (siRNAs) by cationic carbosilane dendrimers, and the interaction of the formed complexes with HeLa and HL-60 cancer cells. Stepwise formation of the complexes accompanied by the evolution of their properties has been observed through the increase of the charge ratio (dendrimer /siRNA). The complexes decrease the viability of both easy-to-transfect cells (HeLa) and hard-to transfect ones (HL-60), indicating a high potential of the cationic carbosilane dendrimers for siRNA delivery into tumor cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
