期刊
JOURNAL OF ADVANCED RESEARCH
卷 18, 期 -, 页码 81-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jare.2019.01.004
关键词
Cationic carbon dots; Fluorescent; Surface passivation; Bioimaging; Gene delivery; Theranostics
资金
- Kerman University of Medical Sciences, Iran
Recently, carbon dots (CDs) have attracted great attention due to their superior properties, such as biocompatibility, fluorescence, high quantum yield, and uniform distribution. These characteristics make CDs interesting for bioimaging, therapeutic delivery, optogenetics, and theranostics. Photoluminescence (PL) properties enable CDs to act as imaging-trackable gene nanocarriers, while cationic CDs with high transfection efficiency have been applied for plasmid DNA and siRNA delivery. In this review, we have highlighted the precursors, structure and properties of positively charged CDs to demonstrate the various applications of these materials for nucleic acid delivery. Additionally, the potential of CDs as trackable gene delivery systems has been discussed. Although there are several reports on cellular and animal approaches to investigating the potential clinical applications of these nanomaterials, further systematic multidisciplinary approaches are required to examine the pharmacokinetic and biodistribution patterns of CDs for potential clinical applications. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of Cairo University.
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