期刊
FRONTIERS IN ONCOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2018.00371
关键词
Fusobacterium; colorectal cancer; tumor microenvironment; epigenetic changes; tumor immunity
类别
资金
- Natural Science Foundation of China [81672738, 81730077, 81372819, 81572596, U1601223]
- National Key R&D Program of China [2016YFC1302301]
- Science and Technology Program of Guangzhou [201704020095]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2016ZT06S252]
- Guangzhou Science and Technology Bureau [2014J4100170, 201704020131]
- Natural Science Foundation of Guangdong Province [2017A030313828]
- Fundamental Research Funds for the Central Universities [17ykjc14]
Colorectal cancer (CRC) is the third most common cancer worldwide and its pathogenesis has been extensively explored over the past decades. Recently, microorganisms in the gastrointestinal tract have emerged as potential etiological agents. In particular, a direct proportional association between Fusobacterium and CRC has been described. Since then, the functional impact of Fusobacterium in CRC development has been studied using various mouse models. Although some epidemiologic studies did not establish an obvious relationship between Fusobacterium and CRC, numerous pathogenic mechanisms leading to the disease have been described. For instance, Fusobacterium can activate the E-cadherin/beta-catenin signaling pathway and is associated with particular epigenetic phenotype, such as microsatellite instability (MSI) and hypermethylation, via its strong adhesive and invasive abilities resulting in malignant transformation of epithelial cells. Also, Fusobacterium could alter the tumor microenvironment (TME) significantly by myeloid-derived suppressor cells (MDSCs), tumor associated macrophages (TAMs), and tumor associated neutrophils (TANs) recruitment and local immune suppression. Herein, we provide an in-depth review of the relationship between Fusobacterium and colorectal cancer. In light of the emergence of microbiome-based therapeutics, potential therapies and preventive strategies for colorectal cancer related to Fusobacterium are also discussed.
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