期刊
ADVANCED FUNCTIONAL MATERIALS
卷 26, 期 47, 页码 8594-8603出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201604192
关键词
-
类别
资金
- La Ligue Nationale Contre le Cancer
- Association pour la Recherche sur les Tumeurs de la Prostate
- Association Francaise contre les Myopathies
- Fondation pour la Recherche Medicale
- international ERA-Net EURONANOMED European Research project Target4Cancer
- China Scholarship Council
- PACA Canceropole
- INCa
- CNRS
- INSERM
Functional materials capable of responding to stimuli intrinsic to diseases are extremely important for specific drug delivery at the disease site. However, developing on-demand stimulus-responsive vectors for targeted delivery is highly challenging. Here, a stimulus-responsive fluorinated bola-amphiphilic dendrimer is reported for on-demand delivery of small interfering RNA (siRNA) in response to the characteristic high level of reactive oxygen species (ROS) in cancer cells. This dendrimer bears a ROS-sensitive thioacetal in the hydrophobic core and positively charged poly(amidoamine) dendrons at the terminals, capable of interacting and compacting the negatively charged siRNA into nanoparticles to protect the siRNA and promote cellular uptake. The ROS-sensitive feature of this dendrimer boosts specific and efficient disassembly of the siRNA/vector complexes in ROS-rich cancer cells for effective siRNA delivery and gene silencing. Moreover, the fluorine tags in the vector enable F-19-NMR analysis of the ROS-responsive delivery process. In addition, this ingenious and distinct bola-amphiphilic dendrimer is also able to combine the advantageous delivery features of both lipid and dendrimer vectors. Therefore, it represents an innovative on-demand stimulus-responsive delivery platform.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据