期刊
ADVANCED FUNCTIONAL MATERIALS
卷 26, 期 48, 页码 8810-8823出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201603197
关键词
biomaterials; bone regeneration; bone morphogenetic proteins; growth factors; scaffolds
类别
资金
- National Natural Science Foundation of China [31330028, 31470923, 31271011]
- National Basic Research Program of China (973 Program) [2012CB933600]
- Major Basic Research Foundation of Shanghai Science and Technique Committee [14JC1490800]
- Shanghai International Incorporation Program [155207111000]
- New Century Excellent Talents in University [NCET-12-0856]
- 111 Project [B14018]
Inspired by the physiological events of the wound healing cascade, the integration of biomaterials and growth factors is generally accepted as an emerging and powerful strategy for bone regenerative therapy. As a type of biological mediator, growth factors play a key role in functional bone regeneration. In this review, recent progress in the enhancement of bone-related growth factors via a biomaterial strategy will be discussed. Two main reinforcing mechanisms, temporal regulation and efficacy manipulation, are described in detail, highlighting the potential capability of biomaterials to harness the interactions between growth factors and specific cells. The effects of biomaterials for promoting bone formation via growth factor-mediated osteogenesis are further elucidated. Finally, an outlook of the prospects in terms of superior communication among growth factors, cells, and biomaterials in the microenvironment is presented, which might provide new directions for the design of medical devices for bone regeneration.
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