期刊
ADVANCED MATERIALS TECHNOLOGIES
卷 4, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/admt.201800350
关键词
artificial synapses; conducting and ionic polymers; live neuronal cells; memristive devices; synaptic prosthesis
资金
- Autonomous Province of Trento-Italy [6.2313.2017/4.6, 6.5408.2017/9.10]
- CARIPARMA FOUNDATION
Functional coupling live neurons through artificial synapses is the primary requirement for their implementation as prosthetic devices or in building hybrid networks. Here, the first evidence of unidirectional, activity dependent, coupling of two live neurons in brain slices via organic memristive devices (OMD) is demonstrated. ODM is a polymeric electrochemical element, which has two terminals for the connection in electrical circuits and which displays hysteresis and rectifying features. OMD coupling is characterized by nonlinear relationships determined by the instantaneous values of OMD resistance that can be controlled by the neuronal activity, and the excitation threshold in the postsynaptic neuron. OMD coupling also has the spike-timing features similar to that of the natural excitatory synapses. Also, OMD-synapses support synchronized delta-oscillations in the two-neuron network. It is proposed that OMD-synapses may enable realization of prosthetic synapses and building hybrid neuronal networks endowed with a capacity of learning, memory, and computation.
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