期刊
CELLS
卷 7, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/cells7100168
关键词
cell cycle; fluorescent proteins; FUCCI; imaging
类别
资金
- Ministry of Education, Science and Culture, Japan [18K16313]
- Grants-in-Aid for Scientific Research [18K16313] Funding Source: KAKEN
Most cytotoxic agents have limited efficacy for solid cancers. Cell-cycle phase analysis at the single-cell level in solid tumors has shown that the majority of cancer cells in tumors is not cycling and is therefore resistant to cytotoxic chemotherapy. Intravital cell-cycle imaging within tumors demonstrated the cell-cycle position and distribution of cancer cells within a tumor, and cell-cycle dynamics during chemotherapy. Understanding cell-cycle dynamics within tumors should provide important insights into novel treatment strategies.
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