期刊
CELLS
卷 8, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cells8010006
关键词
Dictyostelium; Polysphondylium; cellular slime mold; DIF; polyketide; drug resource; mitochondria; cancer; diabetes; Trypanosoma cruzi
类别
资金
- JSPS KAKENHI [09680686, 15590123, 17590115, 19590136, 21590090, 24590110, 15K07964, 25350959, 16H03279]
- Research for Promoting Technology Seeds [05-018, 05-021]
- Universities and Public Research Institutions, Accelerating Utilization of University IP Program
- Exploratory Research Type, Feasibility Study Stage, Adaptable and Seamless Technology Transfer Program through Target-Driven R&D (A-STEP) from Japan Science and Technology Agency (JST) [AS232Z00488G]
- Platform Project for Supporting in Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from Japan Agency for Medical Research and Development (AMED) [JP18am0101100]
- Kobayashi International Scholarship Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [17590115, 25350959, 15K07964, 15590123, 16H03279, 21590090, 19590136, 09680686] Funding Source: KAKEN
The cellular slime mold Dictyostelium discoideum is an excellent model organism for the study of cell and developmental biology because of its simple life cycle and ease of use. Recent findings suggest that Dictyostelium and possibly other genera of cellular slime molds, are potential sources of novel lead compounds for pharmacological and medical research. In this review, we present supporting evidence that cellular slime molds are an untapped source of lead compounds by examining the discovery and functions of polyketide differentiation-inducing factor-1, a compound that was originally isolated as an inducer of stalk-cell differentiation in D. discoideum and, together with its derivatives, is now a promising lead compound for drug discovery in several areas. We also review other novel compounds, including secondary metabolites, that have been isolated from cellular slime molds.
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