期刊
CANCERS
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/cancers10120493
关键词
metastization; invasion; migration; microRNAs; high-risk HPV; cervical cancer; head and neck cancer; anogenital cancer
类别
资金
- Portuguese League Against Cancer-Regional Nucleus of the North (Liga Portuguesa Contra o Cancro-Nucleo Regional do Norte)
- Norte 2020 project Early-stage cancer treatment, driven by context of molecular imaging (ESTIMA) [NORTE-01-0145-FEDER-000027]
- COMPETE 2020 project [POCI-01-0145-FEDER-006939]
- Research Center of the Portuguese Oncology Institute of Porto [PI86-CI-IPOP-66-2017]
High-risk human papillomavirus (HPV)-driven cancers represent a major health concern worldwide. Despite the constant effort to develop and promote vaccination against HPVs, there is still a high percentage of non-vaccinated population. Furthermore, secondary prevention programs are not ubiquitous worldwide and not widely followed. Metastatic disease is the cause of the great majority of cancer-associated deaths, making it essential to determine its underlying mechanisms and to identify actionable anti-metastatic targets. Within certain types of cancer (e.g., head and neck), HPV-positive tumors show different dissemination patterns when compared with their HPV-negative counterparts, implicating HPV-related factors in the metastatic process. Among the many groups of biomolecules dysregulated by HPV, microRNAs have recently emerged as key regulators of carcinogenesis, able to control complex processes like cancer metastization. In this review, we present recent data on the role of microRNAs in the metastization of HPV-related cancers and on their possible clinical relevance as biomarkers of metastatic disease and/or as therapeutic targets.
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