期刊
JOURNAL OF CLINICAL MEDICINE
卷 8, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/jcm8010098
关键词
coronary artery disease; gender; sex; women; diabetes; cell signaling; biomarkers
资金
- Italian Istituto Nazionale Ricerche Cardiovascolari(I.N.R.C.)
- National Research, Development, and Innovation Office of Hungary [OTKA KH_17 125570, NVKP 16-1-2016-0017, VEKOP-2.3.2-16-2016-00002]
- Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary of the Semmelweis University
- European Cooperation in Science and Technology [COST EU-CARDIOPROTECTION CA16225, CARDIORNA CA17129]
- CARIPLO
- PRIN
Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in the evaluation of CAD and IHD in diabetic women.
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