期刊
JOURNAL OF CLINICAL MEDICINE
卷 7, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/jcm7100340
关键词
aging; muscle tissue composition; echogenicity; sarcopenia; muscle quality; quantitative ultrasound; computed tomography; muscle strength; metabolic status; myosteatosis
资金
- VA Capitol Health Care Network Pilot Grant Program [VISN 5, 688]
- VA Historically Black Colleges and Universities Research Scientist Training Program (VA-HBCU RSTP) from the Rehabilitation R&D Service at the VA Office of Research and Development [1IK2RX001854]
- National Center for Advancing Translational Sciences, National Institutes of Health (NCATS/NIH), through the Clinical and Translational Science Awards Program [CTSA UL1TR000101]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000101, UL1TR001409] Funding Source: NIH RePORTER
- Veterans Affairs [IK2RX001854] Funding Source: NIH RePORTER
Estimates of muscle tissue composition may have greater prognostic value than lean body mass levels regarding health-related outcomes. Ultrasound provides a relatively low cost, safe, and accessible mode of imaging to assess muscle morphology. The purpose of this study was to determine the construct validity of muscle echogenicity as a surrogate measure of muscle quality in a sample of older, predominantly African American (AA) participants. We examined the association of rectus femoris echogenicity with mid-thigh computed tomography (CT) scan estimates of intra- and intermuscular adipose tissue (IMAT), basic metabolic parameters via blood sample analysis, muscle strength, and mobility status. This observational study was conducted at a federal medical center and included 30 community-dwelling men (age, 62.5 +/- 9.2; AA, n = 24; Caucasian, n = 6). IMAT estimates were significantly associated with echogenicity (r = 0.73, p < 0.001). Echogenicity and IMAT exhibited similar associations with the two-hour postprandial glucose values and high-density lipoproteins values (p < 0.04), as well as grip and isokinetic (180 degrees/s) knee extension strength adjusted for body size (p < 0.03). The significant relationship between ultrasound and CT muscle composition estimates, and their comparative association with key health-related outcomes, suggests that echogenicity should be further considered as a surrogate measure of muscle quality.
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