期刊
NATURE MICROBIOLOGY
卷 4, 期 1, 页码 97-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41564-018-0290-8
关键词
-
类别
资金
- National Natural Science Foundation of China [21735006, 91413119]
- joint Peking-Tsinghua Center for Life Sciences
- National Natural Science Foundation of China General Program [31370878]
- US NIH [R01AI098995]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-355350/396037]
- Canadian Institutes for Health Research [MOP-119295]
Bacterial quorum-sensing autoinducers are small chemicals released to control microbial community behaviours. N-(3-oxo-dodecanoyl) homoserine lactone, the autoinducer of the Pseudomonas aeruginosa Lasl-LasR circuitry, triggers significant cell death in lymphocytes. We found that this molecule is incorporated into the mammalian plasma membrane and induces dissolution of eukaryotic lipid domains. This event expels tumour necrosis factor receptor 1 into the disordered lipid phase for its spontaneous trimerization without its ligand and drives caspase 3-caspase 8-mediated apoptosis. In vivo, P. aeruginosa releases N-(3-oxo-dodecanoyl) homoserine lactone to suppress host immunity for its own better survival; conversely, blockage of caspases strongly reduces the severity of the infection. This work reveals an unknown communication method between microorganisms and the mammalian host and suggests interventions of bacterial infections by intercepting quorum-sensing signalling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据