Homochiral Metal Organic Frameworks and Their Usage for the Enantio-Purification of Racemic Drugs

Three new homochiral MOFs (MOF-808-S-ibuprofen, MOF-808-S-proline and MOF-808-S-lactic acid) were synthesized via the post synthetic modification of achiral MOF-808 and were characterized by various analytical tools. The new homochiral MOFs (HCMOFs) were examined for the enantioselective adsorption of racemic drugs. The n-hexane solution of racemic ibuprofen, ketoprofen and flurbiprofen were allowed to adsorb in the chiral channels of the HCMOFs. The drugs were desorbed form porous HCMOFs and analysed by chiral HPLC. MOF-808-S-ibuprofen selectively adsorbed R-ibuprofen and R-ketoprofen with enantiomeric excess (ee) of 50 and 56% respectively.