期刊
NEUROPHOTONICS
卷 5, 期 4, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.NPh.5.4.045005
关键词
diffuse correlation spectroscopy; near-infrared spectroscopy; cerebral blood flow; cerebral autoregulation; neuromonitoring; subarachnoid hemorrhage; neurocritical care
资金
- National Institutes of Health [NINDS R21-NS094828, NIGMS R01-GM116177, 1S10RR023401, 1S10RR019307, 1S10RR023043]
- Andrew David Heitman Foundation
- Massachusetts General Hospital Executive Committee on Research (ECOR)
Monitoring of cerebral blood flow (CBF) and autoregulation are essential components of neurocritical care, but continuous noninvasive methods for CBF monitoring are lacking. Diffuse correlation spectroscopy (DCS) is a noninvasive diffuse optical modality that measures a CBF index (CBFi) in the cortex microvasculature by monitoring the rapid fluctuations of near-infrared light diffusing through moving red blood cells. We tested the feasibility of monitoring CBFi with DCS in at-risk patients in the Neurosciences Intensive Care Unit. DCS data were acquired continuously for up to 20 h in six patients with aneurysmal subarachnoid hemorrhage, as permitted by clinical care. Mean arterial blood pressure was recorded synchronously, allowing us to derive autoregulation curves and to compute an autoregulation index. The autoregulation curves suggest disrupted cerebral autoregulation in most patients, with the severity of disruption and the limits of preserved autoregulation varying between subjects. Our findings suggest the potential of the DCS modality for noninvasive, long-term monitoring of cerebral perfusion, and autoregulation. (c) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据