期刊
FRONTIERS IN PSYCHIATRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2018.00751
关键词
autism spectrum disorder; comorbidity; epilepsy; gastrointestinal disorders; immune function; sleep
类别
资金
- NIHR Maudsley Biomedical Research Centre
- UK Tuberous Sclerosis Association
- University of London Basil Davies bequest
- Medical Research Council (MRC)
- National Health and Medical Research Fellowship [1077966]
- Cooperative Research Centre for Living with Autism (Autism CRC)
- Australian Government's Cooperative Research Centres Program
Co-occurring medical disorders and associated physiological abnormalities in individuals with autism spectrum disorder (ASD) may provide insight into causal pathways or underlying biological mechanisms. Here, we review medical conditions that have been repeatedly highlighted as sharing the strongest associations with ASD-epilepsy, sleep, as well as gastrointestinal and immune functioning. We describe within each condition their prevalence, associations with behavior, and evidence for successful treatment. We additionally discuss research aiming to uncover potential aetiological mechanisms. We then consider the potential interaction between each group of conditions and ASD and, based on the available evidence, propose a model that integrates these medical comorbidities in relation to potential shared aetiological mechanisms. Future research should aim to systematically examine the interactions between these physiological systems, rather than considering these in isolation, using robust and sensitive biomarkers across an individual's development. A consideration of the overlap between medical conditions and ASD may aid in defining biological subtypes within ASD and in the development of specific targeted interventions.
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