期刊
INFECTION AND DRUG RESISTANCE
卷 11, 期 -, 页码 1907-1920出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S170715
关键词
systematic review; ARB; clinical ARGs; environmental ARGs; ARGDs; South Africa
资金
- National Research Foundation [112851]
- South African Research Chairs Initiative in Water Quality and Wastewater Management
A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their spread. Fifty-three articles were included. The prevalence of a wide range of antimicrobial-resistant bacteria and their genes was reviewed. Based on the studies reviewed in this systematic review, mutation was found to be the main genetic element investigated. All settings shared 39 ARGs and ARGDs. Despite the fact that ARGs found in clinical settings are present in the environment, in reviewed articles only 12 were found to be shared between environmental and clinical settings; the inclusion of farm settings with these two settings increased this figure to 32. Data extracted from this review revealed farm settings to be one of the main contributors of antibiotic resistance in healthcare settings. ARB, ARGs, and ARGDs were found to be ubiquitous in all settings examined.
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