期刊
FRONTIERS IN GENETICS
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2018.00542
关键词
FGF10; craniofacial development; palate; salivary gland; lacrimal gland; inner ear; eyelid; taste papillae
资金
- NIDCR [R35-DE026602]
- Academy of Sciences of the Czech Republic [RVO 68378050]
- MEYS [LM2015040]
- ERDF [CZ.02.1.01/0.0/0.0/16_013/0001789, CZ.1.05/2.1.00/19.0395, CZ.1.05/1.1.00/02.0109]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R35DE026602] Funding Source: NIH RePORTER
Members of the fibroblast growth factor (FGF) family have myriad functions during development of both non-vertebrate and vertebrate organisms. One of these family members, FGF10, is largely expressed in mesenchymal tissues and is essential for postnatal life because of its critical role in development of the craniofacial complex, as well as in lung branching. Here, we review the function of FGF10 in morphogenesis of craniofacial organs. Genetic mouse models have demonstrated that the dysregulation or absence of FGF10 function affects the process of palate closure, and FGF10 is also required for development of salivary and lacrimal glands, the inner ear, eye lids, tongue taste papillae, teeth, and skull bones. Importantly, mutations within the FGF10 locus have been described in connection with craniofacial malformations in humans. A detailed understanding of craniofacial defects caused by dysregulation of FGF10 and the precise mechanisms that underlie them offers new opportunities for development of medical treatments for patients with birth defects and for regenerative approaches for cancer patients with damaged gland tissues.
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