期刊
CANCER MANAGEMENT AND RESEARCH
卷 10, 期 -, 页码 6257-6261出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S177244
关键词
colorectal cancer; genetic; lncRNA; susceptibility; MALAT1
类别
Introduction: Colorectal cancer (CRC) remains a major public health concern worldwide. However, the detailed molecular mechanisms of CRC remain poorly understood. Methods: In the current study, we evaluated associations of four genetic variants located in the promoter and gene region of long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (lnc RNA MALATl) with CRC susceptibility among a Chinese population with 966 CRC cases and 988 healthy controls, using a two-stage, case control study design (400 CRC cases and 400 controls in stage 1, and 566 CRC cases and 588 controls in stage 2). Results: We found that the minor alleles of rs619586 (OR=0.73; 95% CI=0.60-0.88; P=0.001) and rs1194338 (OR=0.80; 95% CI=0.70-0.92; P=0.001) were significantly associated with decreased CRC susceptibility. Compared with those with rs619586 -AA genotype, the risk of CRC was significantly lower in individuals with AG genotype (OR=0.76; 95% CI=0.61-0.95) and GG genotype (OR=0.46; 95% CI=0.23-0.90). Compared with those with rs1194338 -CC genotype, the risk of CRC was significantly lower in individuals with AC genotype (OR=0.79; 95% CI=0.65-0.95) and AA genotype (OR=0.68; 95% CI=0.51-0.89). Conclusion: Taken together, our findings provided strong evidence for the hypothesis that genetic variants in IncRNA MALAT1 might contribute to the carcinogenesis of CRC.
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