期刊
CANCER MANAGEMENT AND RESEARCH
卷 10, 期 -, 页码 5639-5647出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S175489
关键词
circulating tumor cell; hepatocellular carcinoma; progression-free survival; overall survival
类别
资金
- National Nature Science Foundation of China [81560535]
- 2018 Innovation Project of Guangxi Graduate Education [JGY2018037, YCBZ2018036]
- 2017 Guangxi Medical University Training Program for Distinguished Young Scholars
- Open Foundation of Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research
- Nature Sciences Found of Guangxi province of China [2013GXNSFAA019138]
Background: This study aimed to determine if the number of circulating tumor cells (CTCs) and changes in their numbers affected tumor recurrence and metastasis after surgical resection in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods: The primary endpoints were overall survival (OS) and progression-free survival (PFS). A total of 42 patients with HCC were selected from the First Affiliated Hospital of Guangxi Medical College from 2014 to 2017. CFCs were counted 1 day prior to and 30 days after surgical excision of HCC using the CanPatrol (TM) system. Results: Numbers of CTCs (> 2 CTCs and > 5 CTCs per 5 ml peripheral blood) were significantly associated with Edmondson stage in HBV-related HCC prior to surgery (P = 0.004 and 0.014, respectively). However there were no significant associations between other tested clinicopathological factors and CTC counts. Postoperative CTC counts (> 2 and > 5) and pre/postoperative change in CTC counts were significantly associated with PFS (P= 0.02, 0.009, and 0.001, respectively), but not with OS. Receiver operating characteristic curve analysis showed that pre/postoperative changes in the CTC count were a better predictor of performance than absolute count. The postoperative Mt count was also significantly associated with positive TP53 expression (P < 0.05). Conclusion: These results demonstrate that postoperative CTC counts (> 2 and > 5) and changes in CTC counts may be independent prognostic indicators for PFS in patients with HBV-related HCC, with the change in number of CTCs showing better predictive performance.
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