Electrospun lipid-coated medicated nanocomposites for an improved drug sustained-release profile

Nanotechnology has been extensively explored for the potential applications in developing materials for sustained drug release. In this study, a modified coaxial electrospinning, characterized by a detachable concentric spinneret, was developed for the fabrication of a new kind of hybrid structural nanomaterials. The hybrid nano-fibers consisted of a drug-free thin layer of glycerol monostearate as the shell and a drug-loaded nanocomposite containing berberine hydrochloride and ethylcellulose as the core, which were confirmed by scanning electron microscopic and transmission electron microscopic results. X-ray diffraction analyses suggested that the drug berberine hydrochloride was converted into an amorphous state with the carrier ethylcellulose in the core section. Fourier transform infrared spectra suggested that all the components were compafible. In vitro dissolution tests verified that the strucfural hybrids can provide an improved drug sustained-release profile than monolithic medicated nanocomposites in terms of initial burst release, sustained-release time and failing-off Lime. The mechanism involving the influences of sheath layer on the drug release behaviour was suggested. The reported protocols pave a new way for fabricating lipid-polymer-based functional nanosfrucfures with accurate sfrucfure-properfy-performance relationship and are useful for developing a series of new functional nanomaferials. (C) 2018 Elsevier Ltd.