期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 106, 期 -, 页码 157-171出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.03.002
关键词
Protein-based nanocage; Bioengineering; Functionalization; Drug delivery; Cancer therapy
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIP, Ministry of Science, ICT & Future Planning) [2015R1A2A1A15056039]
- National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea [1420390]
- KIST Institutional Program [2E26320]
- National Research Foundation of Korea [2015R1A2A1A15056039] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nature, in its wonders, presents and assembles the most intricate and delicate protein structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these proteins, cage-like multimeric proteins provide spatial control to biological processes and also compartmentalizes compounds that may be toxic or unstable and avoids their contact with the environment Protein-based nanocages are of particular interest because of their potential applicability as drug delivery carriers and their perfect and complex symmetry and ideal physical properties, which have stimulated researchers to engineer, modify or mimic these qualities. This article reviews various existing types of protein-based nanocages that are used for therapeutic purposes, and outlines their drug-loading mechanisms and bioengineering strategies via genetic and chemical functionalization. Through a critical evaluation of recent advances in protein nanocage-based drug delivery in vitro and in vivo, an outlook for de novo and in silico nanocage design, and also protein-based nanocage preclinical and future clinical applications will be presented. (C) 2016 Elsevier B.V. All rights reserved.
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