期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 100, 期 -, 页码 158-182出版社
ELSEVIER
DOI: 10.1016/j.addr.2015.12.008
关键词
Broadband dielectric spectroscopy; Amorphous drugs; Physical stability; Molecular mobility; Dielectric relaxations; Crystallization; Elevated pressure
资金
- National Science Centre, Poland [2015/16/W/NZ7/00404]
In recent years, there is a growing interest in improving the physicochemical stability of amorphous pharmaceutical solids due to their very promising applications to manufacture medicines characterized by a better water solubility, and consequently by a higher dissolution rate than those of their crystalline counterparts. In this review article, we show that the molecular mobility investigated both in the supercooled liquid and glassy states is the crucial factor required to understand molecular mechanisms that govern the physical stability of amorphous drugs. We demonstrate that pharmaceuticals can be thoroughly examined by means of the broadband dielectric spectroscopy, which is a very useful experimental technique to explore different relaxation processes and crystallization kinetics as well. Such studies conducted in the wide temperature and pressure ranges provide data needed in searching correlations between properties of molecular dynamics and crystallization process, which are aimed at developing effective and efficient methods for stabilizing amorphous drugs. (c) 2015 Elsevier B.V. All rights reserved.
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