期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 97, 期 -, 页码 28-40出版社
ELSEVIER
DOI: 10.1016/j.addr.2015.10.013
关键词
Discoidin domain receptors; Integrin; Proteoglycan; Syndecan; Adhesion; Migration
资金
- Danish National Research Foundation
- Novo Nordisk Fonden
- Lundbeck Fonden
- Danish Council of Natural Sciences
- Medical Research Council UK [G0701121]
- Biotechnology and Biological Sciences Research Council UK [BB/1011226/1]
- Norwegian Centre of Excellence grant [223250]
- BBSRC [BB/I011226/1] Funding Source: UKRI
- MRC [G0701121] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I011226/1] Funding Source: researchfish
- Medical Research Council [G0701121] Funding Source: researchfish
Cell responses to the extracellular matrix depend on specific signaling events. These are important from early development, through differentiation and tissue homeostasis, immune surveillance, and disease pathogenesis. Signaling not only regulates cell adhesion cytoskeletal organization and motility but also provides survival and proliferation cues. The major classes of cell surface receptors for matrix macromolecules are the integrins, discoidin domain receptors, and transmembrane proteoglycans such as syndecans and CD44. Cells respond not only to specific ligands, such as collagen, fibronectin, or basement membrane glycoproteins, but also in terms of matrix rigidity. This can regulate the release and subsequent biological activity of matrix-bound growth factors, for example, transforming growth factor-beta. In the environment of tumors, there may be changes in cell populations and their receptor profiles as well as matrix constitution and protein cross-linking. Here we summarize roles of the three major matrix receptor types, with emphasis on how they function in tumor progression. (C) 2015 Elsevier B.V. All rights reserved.
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