期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 97, 期 -, 页码 260-269出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2015.11.019
关键词
ECM; ECM-like biomaterials; ECM-mimics; Cancer therapy; Electrospun release systems; Proteins
资金
- Fraunhofer-Gesellschaft
- Medical Faculty of the Eberhard Karls University Tubingen
- Fraunhofer IGB Stuttgart
- Ministry of Science, Research and the Arts of Baden-Wurttemberg [33-729.55-3/214, SI-BW 01222-91]
- Deutsche Forschungsgemeinschaft [SCHE 701/7-1]
- European Union [604531, FP7-NMP-2013-SME-7]
Regenerative strategies such as stem cell-based therapies and tissue engineering applications are being developed with the aim to replace, remodel, regenerate or support damaged tissues and organs. In addition to careful cell type selection, the design of appropriate three-dimensional (3D) scaffolds is essential for the generation of bio-inspired replacement tissues. Such scaffolds are usually made of degradable or non-degradable biomaterials and can serve as cell or drug carriers. The development of more effective and efficient drug carrier systems is also highly relevant for novel cancer treatment strategies. In this review, we provide a summary of current approaches that employ ECM and ECM-like materials, or ECM-synthetic polymer hybrids, as biomaterials in the field of regenerative medicine. We further discuss the utilization of such materials for cell and drug delivery, and highlight strategies for their use as vehicles for cancer therapy. (C) 2015 The Authors. Published by Elsevier B.V.
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