期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 100, 期 -, 页码 133-146出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2015.11.021
关键词
Low-frequency Raman spectroscopy; Chemometrics; Physical stability; Drug delivery systems
The success rate for drug discovery and the development of innovative therapeutic strategies are intimately related to the physical properties of the solid-state condensed matter, which have direct influence on the bioavailability of Active Pharmaceutical Ingredients. In order to transform a new molecule in efficient drug, the material is brought into an amorphous state using various manufacturing processes including freeze drying, spray drying, hot melt extrusion and loading in different delivery devices. The infrared and Raman spectroscopic analyses used for exploring disordered and amorphous states, for the monitoring of the drug physical stability in drug delivery systems are described in this review. (c) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据