期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 106, 期 -, 页码 355-366出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.04.031
关键词
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资金
- European Community [281035-2-EU-TRANS-INT]
- MINECO-FEDER [BIO2013-40716-R]
- Generalitat de Catalunya [XRB, 2014-SGR-521]
- MINECO (Government of Spain)
- Juan de la Cierva fellowship
- FPU fellowship
The oral route is the preferred for the administration of drugs; however, it has some serious limitations. One of the main disadvantages is poor permeability across the intestinal barrier. Various approaches are currently being adopted to overcome this issue. In this review, we describe the alternatives that use peptides to enhance intestinal absorption. First, we define the various sources of peptide enhancers followed by the analysis of the absorption mechanism used. We then comment on the possible toxic effects derived from their use as permeation enhancers, as well as potential formulation strategies. Finally, the advantages and drawbacks of peptides as intestinal enhancers are examined. (C) 2016 Elsevier B.V. All rights reserved.
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