期刊
MATERIALS RESEARCH EXPRESS
卷 6, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/2053-1591/aae6f3
关键词
near-field melt electrospinning; cell alignment; poly(epsilon-caprolactone); micro-pattern
资金
- National Natural Science Foundation of China [81801830]
- Key Project of Science and Technology of Guangdong Province, China [2015B010124001]
- Project of Science and Technology of Guangdong Province [2017B090911012, 2015B090921007, 2015B010102014]
- R&D Key Projects from Guangdong Province [2015B010133005]
- Guangdong Innovative Research Team Program [2014ZT05G157]
- Project of Science and Technology of Foshan City [2015IT100152]
- Applied Science and Technology Development Foundation of Guangdong [2015B090921007]
- Guangdong Provincial Natural Science Foundation [2015A030312008, 2016A030308016]
- Key Project of Science and Technology of Guangdong Province: study of super-resolution CT-US-4D guided system, Training program for outstanding young teachers in higher education institutions of Guangdong Province [YQ2015056]
- Guangdong High-level Personnel of Special Support Program (Outstanding young scholar in science and technology innovation) [2014TQ01X212]
- Project of Public Welfare Research of Guangdong Province [2015B010104006]
- University Innovation and Entrepreneurship Education Major Project of Guangzhou City [201709P05]
- Science and Technology Planning Project of Guangzhou City of China [201604016084]
Cell alignment is widely found in various tissues and organs in vivo, thus engineering of cell alignment is a significant issue in tissue engineering. Near-field melt electrospinning (NMES) is an emerging technique to produce polymer microfibers, which has been increasingly used to prepare scaffold; however, the effect of NMES micro-pattern on cell orientation guidance such as cell alignment has not been investigated systematically yet. In this study, poly(epsilon-caprolactone) (PCL) micro-line array was fabricated by NMES for cell alignment studies. Different from most previous reports, PCL micro-line array with improved fiber deposition accuracy and decreased fiber spacing (small to 10 mu m) was achieved by regulating the applied voltage and nozzle-to-collector distance. Cell alignment was observed on PCL micro-line arrays and the alignment effect weakened with the increase of the space between micro-lines. By MTT analysis, cells cultured on NMES PCL micro-line arrays showed better viability than that on plain substrate without PCL, which was advantageous over conventional electrospun nanofibers.
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