期刊
BIOCHIMIE
卷 109, 期 -, 页码 1-17出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2014.11.016
关键词
Eukaryotic ribosomal proteins; Involvement of ribosomal proteins in the intersubunit bridges; Implication of ribosomal proteins in ribosomal ligands binding; Functional roles of ribosomal proteins in translation
资金
- Russian Foundation for Basic Research [14-04-00709]
- Presidium of the Russian Academy of Sciences (the Program Molecular and Cell Biology) [6.10]
Ribosomal proteins (rps) are constituents of ribosomal subunits together with the rRNAs, and the work of the ribosomes is based on highly cooperative interactions involving these biopolymers. Eukaryotic ribosomal subunits contain proteins that have bacterial counterparts as well as proteins specific only to eukaryotes and archaea and proteins unique to eukaryotes. Roles of eukaryotic rps in functioning of the translation machinery are studied in less detail than those of bacterial ones. However, application of various structural, biochemical and genetic approaches made it possible to obtain data suggesting implication of many particular eukaryotic rps in binding of participants of translation process (ribosomal ligands). Here we present a review on these data as well as their analysis aimed to reveal conserved and eukaryote-specific functions of eulcaryotic rps in the work of translational machinery. (C) 2014 Elsevier B.V. and Societe francaise de biochimie et biologie Moleculaire (SFBBM). All rights reserved.
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