期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02723
关键词
microvesicles and exosomes; inflammation; platelet-derived microvesicles; leukocyte-derived microvesicles; endothelial-derived microvesicles
类别
资金
- Alexander von Humboldt Foundation
- German Research Fundation (DFG) [LU2061/4-1]
- Deutsche Krebshilfe [111184]
- DFG [KO4103/4-1]
- MINIATURA 2 grant from the National Science Center [2018/02/X/NZ5/00243]
- Sofja Kovalevskaja Award 2012
The terms microparticles (MPs) and microvesicles (MVs) refer to large extracellular vesicles (EVs) generated from a broad spectrum of cells upon its activation or death by apoptosis. The unique surface antigens of MPs/MVs allow for the identification of their cellular origin as well as its functional characterization. Two basic aspects of MP/MV functions in physiology and pathological conditions are widely considered. Firstly, it has become evident that large EVs have strong procoagulant properties. Secondly, experimental and clinical studies have shown that MPs/MVs play a crucial role in the pathophysiology of inflammation-associated disorders. A cardinal feature of these disorders is an enhanced generation of platelets-, endothelial-, and leukocyte-derived EVs. Nevertheless, anti-inflammatory effects of miscellaneous EV types have also been described, which provided important new insights into the large EV-inflammation axis. Advances in understanding the biology of MPs/MVs have led to the preparation of this review article aimed at discussing the association between large EVs and inflammation, depending on their cellular origin.
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