期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02976
关键词
host defense against pathogenic bacteria; disease tolerance; tuberculosis; innate immunity; adaptive immunity
类别
资金
- Canadian Institute of Health Research (CIHR) Foundation Grant [FDN-143273]
- Fonds de la Recherche du Quebec - Sante (FRQS) Award
- Strauss Chair in Respiratory Diseases
- FRQS
- German Research Foundation (DFG)
Host defense strategies against infectious diseases are comprised of both host resistance and disease tolerance. Resistance is the ability of the host to prevent invasion or to eliminate the pathogen, while disease tolerance is defined by limiting the collateral tissue damage caused by the pathogen and/or the immune response without exerting direct effects on pathogen growth. Our incomplete understanding of host immunity against tuberculosis (TB) is predominately rooted in our bias toward investigating host resistance. Thus, we must refocus our efforts to understand the entire spectrum of immunity against M. tuberculosis to control TB.
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