期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02809
关键词
CD244; tumor immune escape; immune exhaustion (IE); signaling lymphocyte activation molecule; MDSC; CD8 cytotoxic T lymphocytes; NK cells and cancer; tumor microenviroment
类别
资金
- Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Cancer Research Program [W81XWH-17-1-0374]
- National Cancer Institute [CA201918-01]
- National Institute on Aging [AG053498]
In cancer, immune exhaustion contributes to the immunosuppressive tumor microenvironment. Exhausted immune cells demonstrate poor effector function and sustained expression of certain immunomodulatory receptors, which can be therapeutically targeted. CD244 is a Signaling Lymphocyte Activation Molecule (SLAM) family immunoregulatory receptor found on many immune cell types-including NK cells, a subset of T cells, DCs, and MDSCs-that represents a potential therapeutic target. Here, we discuss the role of CD244 in tumor-mediated immune cell regulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据