期刊
ADDICTION
卷 112, 期 2, 页码 207-214出版社
WILEY
DOI: 10.1111/add.13451
关键词
Alcohol; bias; epidemiology; moderate drinking; mortality; selection bias
资金
- [1RC1AA018907-01]
- [1R01AA019939-01A1]
Selection biases may lead to systematic overestimate of protective effects from 'moderate' alcohol consumption. Overall, most sources of selection bias favor low-volume drinkers in relation to non-drinkers. Studies that attempt to address these types of bias generally find attenuated or non-significant relationships between low-volume alcohol consumption and cardiovascular disease, which is the major source of possible protective effects on mortality from low-volume consumption. Furthermore, observed mortality effects among established low-volume consumers are of limited relevance to health-related decisions about whether to initiate consumption or to continue drinking purposefully into old age. Short of randomized trials with mortality end-points, there are a number of approaches that can minimize selection bias involving low-volume alcohol consumption.
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