期刊
ADVANCED SCIENCE
卷 6, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/advs.201801615
关键词
aggregation-induced absorption enhancement; brain gliomas; deep photoacoustic imaging; mesoionic dyes; second near-infrared window
资金
- National Science Foundation of China [91859113, 81501534, 81571744]
- Excellent Youth Foundation of Fujian Scientific Committee [2018J06024]
- Fundamental Research Funds for the Central Universities [20720170065, 20720180050]
- Science and Technology Planning Project of Shandong Province [2015GSF118161, 2014GSF118046]
- Taishan scholars program [tsqn20161070]
- Scientific Research Foundation of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics [2016ZY002]
The delineation of brain gliomas margins still poses challenges to precise imaging and targeted therapy, mainly due to strong light attenuation of the skull and high background interference. With deep penetration and high sensitivity, photoacoustic (PA) imaging (PAI) in the second near-infrared (NIR II) window holds great potential for brain gliomas imaging. Herein, mesoionic dye A1094 encapsulated in Arg-Gly-Asp-modified hepatitis B virus core protein (RGD-HBc) is designed and synthesized for effective NIR II PAI of brain gliomas. An aggregation-induced absorption enhancement mechanism is discovered in vitro and in vivo. It is also demonstrated that A1094@RGD-HBc, with an enhanced absorption in the NIR II window, displays ninefold PA signal amplification in vivo, allowing for precise PAI of the brain gliomas at a depth up to 5.9 mm. In addition, with the application of above mentioned agent, high-resolution PAI and ultrasensitive single photon emission computed tomography images of brain gliomas are acquired with accurate co-localization. Collectively, the results suggest great promise of A1094@RGD-HBc for diagnostic imaging and precise delineation of brain gliomas in clinical applications.
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