期刊
ACS INFECTIOUS DISEASES
卷 5, 期 1, 页码 123-130出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.8b00230
关键词
antibacterial; antibiotic; MRSA; peptides
资金
- National Key Research and Development Program of China [2017YFC1600305, 2018YFD0500506]
- National Natural Science Foundation of China [31772796]
- Beijing Dairy Industry Innovation Team
- Beijing Municipal Science and Technology Project [D171100002017004]
The development and rapid spread of multi drug resistant (MDR) bacteria cause severe public crises. New antibacterial compounds are urgently needed to treat bacterial infections. By circumventing the disadvantages of cationic peptides here, we engineered a short, linear, low-cationic peptide bacaucin-1a, which exhibited remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Bacaucin-1a was efficient in the prevention of MRSA associated infections in both in vitro and in vivo models with a unique mode of action. The discovery of low cationic antibiotic candidates will extend our antibiotic pipeline in the fight against antibiotic resistant bacteria.
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