期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 5, 期 8, 页码 3720-3734出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b01228
关键词
cytoskeletal network; mechanical behavior; theory; modeling; finite element method; molecular dynamics simulation
资金
- National Natural Science Foundation of China [11672268, 11621062, 91748209]
- Zhejiang Provincial Natural Science Foundation of China [LR16A020001]
- Fundamental Research Funds for Central Universities of China [2017FZA4029]
- Research Grants Council of the Hong Kong Special Administration Region [HKU 17205114, HKU 17211215, HKU 17257016]
The cytoskeleton, a dynamic network of biopolymers with their associated cross-linking and motor proteins, is responsible for stabilizing cell shape and driving cell movement. This paper aims to provide an overview of the theoretical and computational approaches that have been developed to understand the dynamic behaviors and underlying mechanisms of actin-based cytoskeletal networks, connecting their microscopic structure to macroscopic performance across various scales, with implications for the observed nonlinear stress-strain relation, viscoelastic properties, stiffening induced by active motors as well as their biological functions in important processes such as cell adhesion, motility, and mechanosensing. In the future, more sophisticated constitutive theories, continuum level, and molecular dynamics-based simulations of biopolymer networks are expected to provide critical insights for understanding the material-structure-function relation in the cytoskeleton of cells and guiding the development of active biomimetic materials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据