4.5 Article

Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment

期刊

NEUROIMAGE-CLINICAL
卷 21, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2018.101617

关键词

Entorhinal cortex; Transentorhinal cortex; Mild cognitive impairment; Braak staging; Cortical thickness; Shape analysis; Longitudinal analysis

资金

  1. National Science Foundation [ACI-1548562]
  2. National Institutes of Health [P41-EB015909, R01-AG048349, R01-DC016784, R01-EB020062]
  3. Phyllis F. Albstein Fund
  4. Kavli Neuroscience Discovery Institute
  5. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB015909] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE ON AGING [R01AG048349] Funding Source: NIH RePORTER

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This study examines the atrophy rates of subjects with mild cognitive impairment (MCI) compared to controls in four regions within the medial temporal lobe: the transentorhinal cortex (TEC), entorhinal cortex (ERC), hippocampus, and amygdala. These regions were manually segmented and then corrected for undesirable longitudinal variability via Large Deformation Diffeomorphic Metric Mapping (LDDMM) based longitudinal diffeomorphometry. Diffeomorphometry techniques were used to compare thickness measurements in the TEC with the ERC. There were more significant changes in thickness atrophy rate in the TEC than medial regions of the entorhinal cortex. Volume measures were also calculated for all four regions. Classifiers were constructed using linear discriminant analysis to demonstrate that average thickness and atrophy rate of TEC together was the most discriminating measure compared to the thickness and volume measures in the areas examined, in differentiating MCI from controls. These findings are consistent with autopsy findings demonstrating that initial neuronal changes are found in TEC before spreading more medially in the ERC and to other regions in the medial temporal lobe. These findings suggest that the TEC thickness could serve as a biomarker for Alzheimer's disease in the prodromal phase of the disease.

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