期刊
NEUROIMAGE-CLINICAL
卷 21, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2018.101650
关键词
Internalizing symptoms; White matter microstructure; Diffusion Tensor Imaging (DTI); Latent profile analysis
类别
资金
- Canadian Institutes of Health Research (CIHR) [MOP 86458]
- Academic Development Fund (UWO)
- Children's Health Research Institute
- Brain Canada
- Canada Foundation for Innovation (CFI)
Dysfunction in cortico-limbic circuitry is implicated in internalizing disorders (i.e., depressive and anxious disorders), but less is known about whether structural variations precede frank disorder and thus potentially mark risk. We therefore examined associations between white matter (WM) tract microstructure in cortico-limbic circuitry at age 7 and concurrent and longitudinal patterns of internalizing symptoms in 42 typically developing girls using Diffusion Tensor Imaging (DTI). Girls' internalizing symptoms were concurrently associated with reduced fractional anisotropy (FA) in segments of the cingulum bundle (CB) and the uncinate fasciculus (UF), bilaterally. Moreover, latent profile analysis showed that girls with increasing internalizing symptoms, based on assessments at ages 3, 6, 7, and 8, had reduced FA in these segments compared to girls with stably low symptoms. These results point to a putative neural mechanism underlying the course of childhood internalizing symptoms.
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