期刊
GENES
卷 9, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/genes9110557
关键词
cyclic peptides; biopharmaceuticals; mRNA display; yeast two hybrid
资金
- National Research Foundation of Korea [2014M3A6A4075060, 2017R1A2B3011543]
- Samsung Science & Technology Foundation [SSTF-BA1702-09]
To date, small molecules and macromolecules, including antibodies, have been the most pursued substances in drug screening and development efforts. Despite numerous favorable features as a drug, these molecules still have limitations and are not complementary in many regards. Recently, peptide-based chemical structures that lie between these two categories in terms of both structural and functional properties have gained increasing attention as potential alternatives. In particular, peptides in a circular form provide a promising scaffold for the development of a novel drug class owing to their adjustable and expandable ability to bind a wide range of target molecules. In this review, we discuss recent progress in methodologies for peptide cyclization and screening and use of bioactive cyclic peptides in various applications.
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