相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice
Tatiana Danilova et al.
DIABETES (2019)
Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes
Cristina Aguayo-Mazzucato et al.
CELL METABOLISM (2018)
Pseudotime Ordering of Single Human -Cells Reveals States of Insulin Production and Unfolded Protein Response
Yurong Xin et al.
DIABETES (2018)
MANF protects human pancreatic beta cells against stress-induced cell death
Elina Hakonen et al.
DIABETOLOGIA (2018)
RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/db
Abraham Neelankal John et al.
ENDOCRINE PATHOLOGY (2018)
Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons
Sophie Calderari et al.
GENOMICS (2018)
XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B
Dong Wang et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)
IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic beta cells
Yuichi Tsuchiya et al.
JOURNAL OF CELL BIOLOGY (2018)
The Unfolded Protein Response and Cell Fate Control
Claudio Hetz et al.
MOLECULAR CELL (2018)
Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
Meirong Bai et al.
NATURE COMMUNICATIONS (2018)
The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates
Violeta Georgieva Tsonkova et al.
MOLECULAR METABOLISM (2018)
Poststroke delivery of MANF promotes functional recovery in rats
Kert Matlik et al.
SCIENCE ADVANCES (2018)
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides
Xiaoxiao Wan et al.
NATURE (2018)
Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway
Jingxing Zhang et al.
EXPERIMENTAL GERONTOLOGY (2017)
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
Daniel A. Cunha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Chunhua Dai et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential
Maria Lindahl et al.
NEUROBIOLOGY OF DISEASE (2017)
Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Ozlem Tufanli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles
Yeawon Kim et al.
TRANSLATIONAL RESEARCH (2017)
MANF regulates hypothalamic control of food intake and body weight
Su Yang et al.
NATURE COMMUNICATIONS (2017)
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
Miriam Cnop et al.
MOLECULAR METABOLISM (2017)
Metabolic Stress and Compromised Identity of Pancreatic Beta Cells
Avital Swisa et al.
FRONTIERS IN GENETICS (2017)
MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex
Kuan-Yin Tseng et al.
ENEURO (2017)
Targeting ABL-IRE1α Signaling Spares ER- Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Shuhei Morita et al.
CELL METABOLISM (2017)
Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance
Tong Wu et al.
ENDOCRINE JOURNAL (2017)
Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes
Sumaira Z. Hasnain et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2016)
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
Britt Adamson et al.
CELL (2016)
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway
Daniel A. Cunha et al.
CELL DEATH AND DIFFERENTIATION (2016)
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation
Marta Szabat et al.
CELL METABOLISM (2016)
Endoplasmic reticulum stress in beta cells and autoimmune diabetes
Amy L. Clark et al.
CURRENT OPINION IN IMMUNOLOGY (2016)
Inhibition of TGF- Signaling Promotes Human Pancreatic -Cell Replication
Sangeeta Dhawan et al.
DIABETES (2016)
Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes
Marcus Lundberg et al.
DIABETES (2016)
Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases
Yeawon Kim et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
Miao Wang et al.
NATURE (2016)
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
James Dooley et al.
NATURE GENETICS (2016)
Immune modulation by MANF promotes tissue repair and regenerative success in the retina
Joana Neves et al.
SCIENCE (2016)
ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
Flora Brozzi et al.
UPSALA JOURNAL OF MEDICAL SCIENCES (2016)
Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes
Emilia Galli et al.
SCIENTIFIC REPORTS (2016)
Characterization of the Role of MANF in Regulating the Secretion of CRELD2
Kentaro Oh-hashi et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2015)
Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells
Hainan Chen et al.
DIABETES (2015)
Human β-Cell Proliferation and Intracellular Signaling: Part 3
Andrew F. Stewart et al.
DIABETES (2015)
High diagnostic yield of clinical exome sequencing in Middle Eastern patients with Mendelian disorders
Tarunashree Yavarna et al.
HUMAN GENETICS (2015)
Enhanced Efficacy of the CDNF/MANF Family by Combined Intranigral Overexpression in the 6-OHDA Rat Model of Parkinson's Disease
Oscar Cordero-Llana et al.
MOLECULAR THERAPY (2015)
Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity
K. Matlik et al.
CELL DEATH & DISEASE (2015)
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
Justin R. Hassler et al.
PLOS BIOLOGY (2015)
Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling
Marta Carrara et al.
ELIFE (2015)
A human beta cell line with drug inducible excision of immortalizing transgenes
Marion Benazra et al.
MOLECULAR METABOLISM (2015)
Pancreatic α Cells are Resistant toMetabolic Stress-induced Apoptosis in Type 2 Diabetes
Laura Marroqui et al.
EBIOMEDICINE (2015)
Functional Characterization of Zebrafish (Danio rerio) Bcl10
Pellegrino Mazzone et al.
PLOS ONE (2015)
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway
Lijian Chen et al.
SCIENTIFIC REPORTS (2015)
The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells
Tongfu Xu et al.
CELL RESEARCH (2014)
β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome
Linshan Shang et al.
DIABETES (2014)
Proteostasis in endoplasmic reticulum-new mechanisms in kidney disease
Reiko Inagi et al.
NATURE REVIEWS NEPHROLOGY (2014)
Age-Dependent Decrease in Chaperone Activity Impairs MANF Expression, Leading to Purkinje Cell Degeneration in Inducible SCA17 Mice
Su Yang et al.
NEURON (2014)
TRIB3 alters endoplasmic reticulum stress-induced β-cell apoptosis via the NF-κB pathway
Ni Fang et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2014)
Spatiotemporal Expression of MANF in the Developing Rat Brain
Haiping Wang et al.
PLOS ONE (2014)
Aberrant islet unfolded protein response in type 2 diabetes
Feyza Engin et al.
SCIENTIFIC REPORTS (2014)
MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells
Maria Lindahl et al.
CELL REPORTS (2014)
Physiological roles of regulated Ire1 dependent decay
Dina S. Coelho et al.
FRONTIERS IN GENETICS (2014)
Differential responses of pancreatic β-cells to ROS and RNS
Gordon P. Meares et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action
Jonathan E. Campbell et al.
CELL METABOLISM (2013)
Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes
Jeng Yie Chan et al.
DIABETES (2013)
Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases
Claire L. Hartley et al.
HUMAN MOLECULAR GENETICS (2013)
Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Secretion and Cell Surface Binding Are Modulated by KDEL Receptors
Mark J. Henderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
The role of aging upon β cell turnover
Jake A. Kushner
JOURNAL OF CLINICAL INVESTIGATION (2013)
Combined modulation of polycomb and trithorax genes rejuvenates β cell replication
Josie X. Zhou et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Exendin-4 inhibits glucolipotoxic ER stress in pancreatic β cells via regulation of SREBP1c and C/EBPβ transcription factors
Yoon Sin Oh et al.
JOURNAL OF ENDOCRINOLOGY (2013)
Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Oxygen-Glucose Deprivation-Induced Cell Damage and Inflammation by Suppressing Endoplasmic Reticulum Stress in Rat Primary Astrocytes
Hua Zhao et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2013)
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Jaeseok Han et al.
NATURE CELL BIOLOGY (2013)
Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model
Riitta Lindstrom et al.
PLOS ONE (2013)
Characterisation of Age-Dependent Beta Cell Dynamics in the Male db/db Mice
Louise S. Dalboge et al.
PLOS ONE (2013)
Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes
Feyza Engin et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
β-cell dedifferentiation in diabetes is important, but what is it?
Gordon C. Weir et al.
ISLETS (2013)
Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease
Susanne Back et al.
BRAIN AND BEHAVIOR (2013)
Mammalian Tribbles Homologs at the Crossroads of Endoplasmic Reticulum Stress and Mammalian Target of Rapamycin Pathways
Robyn Cunard
SCIENTIFICA (2013)
Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells
Kentaro Oh-Hashi et al.
CELLULAR & MOLECULAR BIOLOGY LETTERS (2013)
Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes
Mari Palgi et al.
BMC GENOMICS (2012)
A Thrombospondin-Dependent Pathway for a Protective ER Stress Response
Jeffrey M. Lynch et al.
CELL (2012)
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Alana G. Lerner et al.
CELL METABOLISM (2012)
MANF regulates dopaminergic neuron development in larval zebrafish
Y. -C. Chen et al.
DEVELOPMENTAL BIOLOGY (2012)
Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
Sarah A. Tersey et al.
DIABETES (2012)
Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes
I. Marhfour et al.
DIABETOLOGIA (2012)
Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion
Christopher C. Glembotski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis
Yan Gao et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Resistance to type 2 diabetes mellitus: a matter of hormesis?
Hubert Kolb et al.
NATURE REVIEWS ENDOCRINOLOGY (2012)
Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance
Masahiro Usui et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2012)
Endoplasmic reticulum stress, obesity and diabetes
Miriam Cnop et al.
TRENDS IN MOLECULAR MEDICINE (2012)
ER stress-induced inflammation: does it aid or impede disease progression?
Abhishek D. Garg et al.
TRENDS IN MOLECULAR MEDICINE (2012)
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction
Ebru Boslem et al.
ISLETS (2012)
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
Decio L. Eizirik et al.
PLOS GENETICS (2012)
ER stress proteins in autoimmune an inflammatory diseases
Daisuke Morito et al.
FRONTIERS IN IMMUNOLOGY (2012)
Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans
Changting Xiao et al.
DIABETES (2011)
Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease
Merja H. Voutilainen et al.
EXPERIMENTAL NEUROLOGY (2011)
Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons
Maarit Hellman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
PDGF signalling controls age-dependent proliferation in pancreatic β-cells
Hainan Chen et al.
NATURE (2011)
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
Ira Tabas et al.
NATURE CELL BIOLOGY (2011)
Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion
Ann-Hwee Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
Esteban N. Gurzov et al.
TRENDS IN CELL BIOLOGY (2011)
Endoplasmic reticulum stress and pancreatic β-cell death
Sonya G. Fonseca et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2011)
GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated β-cell damage in Akita mice
Shunsuke Yamane et al.
JOURNAL OF DIABETES INVESTIGATION (2011)
Type 2 diabetes as an inflammatory disease
Marc Y. Donath et al.
NATURE REVIEWS IMMUNOLOGY (2011)
p38 Mitogen-Activated Protein Kinase is Involved in Endoplasmic Reticulum Stress-Induced Cell Death and Autophagy in Human Gingival Fibroblasts
Do-Sung Kim et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)
Ductal Origin Hypothesis of Pancreatic Regeneration under Attack
Jake A. Kushner et al.
CELL METABOLISM (2010)
MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
Isabella Artner et al.
DIABETES (2010)
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells
R. J. Kaufman et al.
DIABETES OBESITY & METABOLISM (2010)
Causes and cures for endoplasmic reticulum stress in lipotoxic beta-cell dysfunction
M. Cnop et al.
DIABETES OBESITY & METABOLISM (2010)
The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
H. Kolb et al.
DIABETOLOGIA (2010)
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes
M. Igoillo-Esteve et al.
DIABETOLOGIA (2010)
Widespread cortical expression of MANF by AAV serotype 7: Localization and protection against ischemic brain injury
Mikko Airavaara et al.
EXPERIMENTAL NEUROLOGY (2010)
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
Sonya G. Fonseca et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Translation Attenuation through elF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells
Sung Hoon Back et al.
CELL METABOLISM (2009)
Age-Dependent Decline in beta-Cell Proliferation Restricts the Capacity of beta-Cell Regeneration in Mice
Shuen-Ing Tschen et al.
DIABETES (2009)
Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Upotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
Daniel A. Cunha et al.
DIABETES (2009)
A murine model of neonatal diabetes mellitus in Glis3-deficient mice
Naoki Watanabe et al.
FEBS LETTERS (2009)
The KDEL receptor: New functions for an old protein
Mirco Capitani et al.
FEBS LETTERS (2009)
Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus
Hainan Chen et al.
GENES & DEVELOPMENT (2009)
ATF6α induces XBP1-independent expansion of the endoplasmic reticulum
Hemamalini Bommiasamy et al.
JOURNAL OF CELL SCIENCE (2009)
Mesencephalic Astrocyte-Derived Neurotrophic Factor Reduces Ischemic Brain Injury and Promotes Behavioral Recovery in Rats
Mikko Airavaara et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2009)
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease
Merja H. Voutilainen et al.
JOURNAL OF NEUROSCIENCE (2009)
Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
Mari Palgi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional
Vimal Parkash et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2009)
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes
Pierre Pirot et al.
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA (2008)
Role of NF-κB in β-cell death
Danielle Melloul
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
How IRe1 reacts to ER stress
David Ron et al.
CELL (2008)
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart
Archana Tadimalla et al.
CIRCULATION RESEARCH (2008)
The role for endoplasmic reticulum stress in diabetes mellitus
Decio L. Eizirik et al.
ENDOCRINE REVIEWS (2008)
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
Leena Haataja et al.
ENDOCRINE REVIEWS (2008)
Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner
Hye-Young Seo et al.
ENDOCRINOLOGY (2008)
Armet, a UPR-upregulated protelin, inhibits cell proliferation and ER stress-induced cell death
Andria Apostolou et al.
EXPERIMENTAL CELL RESEARCH (2008)
Insulin signaling and the general amino acid control response - Two distinct pathways to amino acid synthesis and uptake
Sharon E. Malmberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Initiation and execution of lipotoxic ER stress in pancreatic β-cells
Daniel A. Cunha et al.
JOURNAL OF CELL SCIENCE (2008)
MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain
Paivi Lindholm et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2008)
From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang et al.
NATURE (2008)
The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells
Kathryn L. Lipson et al.
PLOS ONE (2008)
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
P. W. Franks et al.
DIABETOLOGIA (2008)
The mechanisms of alloxan- and streptozotocin-induced diabetes
S. Lenzen
DIABETOLOGIA (2008)
A molecular specificity code for the three mammalian KDEL receptors
Irina Raykhel et al.
JOURNAL OF CELL BIOLOGY (2007)
Formation and regeneration of the endocrine pancreas
Sangeeta Dhawan et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1
Keisuke Yamamoto et al.
DEVELOPMENTAL CELL (2007)
ATF6α optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
Jun Wu et al.
DEVELOPMENTAL CELL (2007)
Effects of the isoform-specific characteristics of ATF6α and ATF6β on endoplasmic reticulum stress response gene expression and cell viability
Donna J. Thuerauf et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Common variants in WFS1 confer risk of type 2 diabetes
Manjinder S. Sandhu et al.
NATURE GENETICS (2007)
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress-mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
Chang-jiang Huang et al.
DIABETES (2007)
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
Pivi Lindholm et al.
NATURE (2007)
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets
H. Elouil et al.
DIABETOLOGIA (2007)
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
D. R. Laybutt et al.
DIABETOLOGIA (2007)
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1 (S)-induced endoplasmic reticulum biogenesis
Rungtawan Sriburi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis
Miriam Cnop et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Pancreas and beta-cell development: from the actual to the possible
L. Charles Murtaugh
DEVELOPMENT (2007)
GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress
Bernardo Yusta et al.
CELL METABOLISM (2006)
p16INK4a induces an age-dependent decline in islet regenerative potential
Janakiraman Krishnamurthy et al.
NATURE (2006)
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
Kathryn L. Lipson et al.
CELL METABOLISM (2006)
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
Umut Oezcan et al.
SCIENCE (2006)
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells
T Yamada et al.
HUMAN MOLECULAR GENETICS (2006)
ER stress and neurodegenerative diseases
D Lindholm et al.
CELL DEATH AND DIFFERENTIATION (2006)
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
O Cabrera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Divergent roles of IRE1α and PERK in the unfolded protein response
M Schröder et al.
CURRENT MOLECULAR MEDICINE (2006)
Mediators of endoplasmic reticulum stress-induced apoptosis
Eva Szegezdi et al.
EMBO REPORTS (2006)
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells
SG Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
AC Riggs et al.
DIABETOLOGIA (2005)
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
D Scheuner et al.
NATURE MEDICINE (2005)
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
N Ohoka et al.
EMBO JOURNAL (2005)
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
J Deng et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Role for activating transcription factor 3 in stress-induced β-cell apoptosis
MG Hartman et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
P Marchetti et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
Disruption of the WFS1 gene in mice causes progressive β-cell loss and impaired stimulus-secretion coupling in insulin secretion
H Ishihara et al.
HUMAN MOLECULAR GENETICS (2004)
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Y Dor et al.
NATURE (2004)
Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease
K Cryns et al.
HUMAN MUTATION (2003)
Activation signal of nuclear factor-κB in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2
M Kaneko et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2003)
TRB3:: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
KY Du et al.
SCIENCE (2003)
被撤回的出版物: Ku70 suppresses the apoptotic translocation of Bax to mitochondria (Retracted article. See vol 9, pg 480, 2007)
M Sawada et al.
NATURE CELL BIOLOGY (2003)
MANF - A new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons
PS Petrova et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2003)
Endoplasmic reticulum stress and diabetes mellitus
E Araki et al.
INTERNAL MEDICINE (2003)
The PERK eukaryotic initiation factor 2α kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
PC Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
H Nishitoh et al.
GENES & DEVELOPMENT (2002)
The GDNF family: Signalling, biological functions and therapeutic value
MS Airaksinen et al.
NATURE REVIEWS NEUROSCIENCE (2002)
Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway
S Oyadomari et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
D Scheuner et al.
MOLECULAR CELL (2001)
Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival
HP Harding et al.
MOLECULAR CELL (2001)
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
KD McCullough et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure
J Ruland et al.
CELL (2001)
PERK mediates cell-cycle exit during the mammalian unfolded protein response
JW Brewer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Regulated translation initiation controls stress-induced gene expression in mammalian cells
HP Harding et al.
MOLECULAR CELL (2000)
EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
M Delépine et al.
NATURE GENETICS (2000)
Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein
T Yoneda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
F Urano et al.
SCIENCE (2000)
分享论文
