期刊
EMERGING MICROBES & INFECTIONS
卷 8, 期 1, 页码 94-102出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2018.1560234
关键词
H7N9; influenza; receptor; ferret; pathogenicity; transmissibility
资金
- National Key Research and Development Project of China [2016YFE0205800, 2016YFD0500304]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB29010102]
- National Science and Technology Major Project [2016ZX10004222]
- Emergency Technology Research Issue on Prevention and Control for Human Infection with A(H7N9) Avian Influenza Virus [10600100000015001206]
- National Natural Science Foundation of China (NSFC) [31870163, 31672586, U1501212]
- CAMS Innovation Fund for Medical Sciences [CIFMS] [2016-I2M-1-014]
- Sanming Project of Medicine in Shenzhen [SZSM201412003]
- Shenzhen Science and Technology Research and Development Project [JCYJ20160427151920801, JCYJ20151029151932602]
- NSFC Innovative Research Group [81621091]
- NSFC [31822055]
- Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS) [2017122]
There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic overall, we characterized the receptor binding and experimentally infected ferrets with highly pathogenic (HP)- and low pathogenic (LP)-H7N9 isolates selected from Wave 5, and compared their pathogenicity and transmissibility with a Wave 1 isolate from 2013. Studies show that A/Anhui/1/2013 (LP) and A/Chicken/Heyuan/16876/2016 (HP) were highly virulent in ferrets, A/Guangdong/Th008/2017 (HP) and A/Chicken/Huizhou/HZ-3/2017 (HP) had moderate virulence and A/Shenzhen/Th001/2016 (LP) was of low virulence in ferrets. Transmission was observed only in ferrets infected with A/Anhui/1/2013 and A/Chicken/Heyuan/16876/2016, consistent with the idea that sicker ferrets had a higher probability to transmit virus to naive animals. Given the Varied virulence and transmissibility observed in circulating H7N9 viruses from Wave 5, we conclude that the current public health risk of H7N9 has not substantially increased compared to 2013 and the circulating viruses are quite diverse.
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