期刊
CURRENT HIV/AIDS REPORTS
卷 16, 期 1, 页码 76-81出版社
SPRINGER
DOI: 10.1007/s11904-019-00420-1
关键词
HIV; Cerebrospinal fluid; Neurogranin
资金
- Swedish Research Council
- European Research Council
- Swedish State Support for Clinical Research (ALFGBG)
- Knut and Alice Wallenberg Foundation
- Swedish Brain Foundation
- Torsten Soderberg Foundation
- NIH [R01 NS094067, R01MH081772, P01 DA026134]
Purpose of ReviewThe aim of this study was to examine the synaptic biomarker neurogranin in cerebrospinal fluid (CSF) in different stages of HIV infection and in relation to what is known about CSF neurogranin in other neurodegenerative diseases.Recent FindingsCSF concentrations of neurogranin are increased in Alzheimer's disease, but not in other neurodegenerative disorder such as Parkinson's disease, frontotemporal dementia, and Lewy body dementia. Adults with HIV-associated dementia have been found to have decreased levels of neurogranin in the frontal cortex, which at least to some extent, may be mediated by the proinflammatory cytokines IL-1 and IL-8.SummaryCSF neurogranin concentrations were in the same range for all groups of HIV-infected individuals and uninfected controls. This either indicates that synaptic injury is not an important part of HIV neuropathogenesis or that CSF neurogranin is not sensitive to the type of synaptic impairment present in HIV-associated neurocognitive disorders.
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